Anti-SHANK1 antibodies are used in the immunodetection of the protein SH3 and multiple ankyrin repeat domains 1. In humans, the canonical protein has a reported length of 2161 amino acid residues and a mass of 225 kDa. Its subcellular localization is in the cytoplasm. Up to 3 different isoforms have been reported for this protein. It is reported to be expressed in the brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. A member of the SHANK protein family, SHANK1 is suspected to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Synonyms for this target antigen include SSTRIP, synamon, SH3 and multiple ankyrin repeat domains protein 1, SSTR-interacting protein, somatostatin receptor-interacting protein, and SPANK-1. A number of SHANK1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.