Anti-HLA-DRB3 antibodies are used in the immunodetection of the protein major histocompatibility complex, class II, DR beta 3. In humans, the canonical protein has a reported length of 266 amino acid residues and a mass of 30 kDa. Its subcellular localization is in the ER, lysosomes, and cell membrane. It is reported to be expressed in professional APCs: monocyte/macrophages, dendritic cells and B cells. A member of the MHC class II protein family, HLA-DRB3 is known to be involved with adaptive immune responses and signal transduction pathways. Post-translational modifications have been described, including ubiquitination and glycosylation. Synonyms for this target antigen include HLA-DPB1, HLA-DR1B, HLA-DR3B, HLA-DRB3*, HLA DRB3, and DRB3. Over 630 citations in the literature describe the use of HLA-DRB3 antibodies in research. Flow Cytometry is a widely used application for these antibodies. In addition, Western Blot is also a common application.