Anti-CTSS antibodies are used in the immunodetection of the protein cathepsin S. In humans, the canonical protein has a reported length of 331 amino acid residues and a mass of 37.5 kDa. Its subcellular localization is in the lysosomes, cytoplasmic vesicles, and is secreted. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Peptidase C1 protein family, CTSS is known to be involved with adaptive immune responses. Post-translational modifications have been described, including glycosylation. The CTSS marker can be used to identify Fibroblastic Reticular Cells (FRC) and Monocytes.* CTSS gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 60 citations in the literature describe the use of CTSS antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4