Anti-ADAM33 antibodies are used in the immunodetection of the protein ADAM metallopeptidase domain 33. In humans, the canonical protein has a reported length of 813 amino acid residues and a mass of 87.7 kDa. Its subcellular localization is in the membrane. Up to 3 different isoforms have been reported for this protein. It is reported to be expressed in all tissues, except liver, with high expression in the placenta, lung, spleen and veins. ADAM33 is known to be involved with proteolysis. Post-translational modifications have been described, including protein cleavage and glycosylation.
The ADAM33 marker can be used to identify Cerebral Cortex CGE Interneurons.* Synonyms for this target antigen include a disintegrin and metalloprotease 33, a disintegrin and metalloproteinase domain 33, disintegrin and reprolysin metalloproteinase family protein, and disintegrin and metalloproteinase domain-containing protein 33. ADAM33 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4