Anti-Semaphorin 3C antibodies are used for the immunodetection of the protein encoded by the SEMA3C gene. In humans, the canonical protein has a reported length of 751 amino acid residues and a mass of 85.2 kDa. It is known to be a secreted protein. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. A member of the Semaphorin protein family, it is known to bind to plexin family members and plays an important role in the regulation of developmental processes.
The semaphorin 3C marker can be used to characterize Upper-Layer Intratelencephalic Neurons, Eccentric Medium Spiny Neurons, Cerebral Cortex CGE Interneurons, Hypothalamus Mammillary Body Neurons, and Midbrain-Derived Inhibitory Neurons.* Other names for this target antigen include SemE, sema E, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C, semaphorin E, and SEMAE. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of Semaphorin 3C antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4