What are Factor IX antibodies?
Anti-Factor IX antibodies are immunoglobulins that specifically recognize and bind Factor IX, a vitamin K-dependent plasma glycoprotein. These antibodies are used for immunodetection across general sample types such as tissue samples, cell lysates, and cultured cells. Factor IX (F9) is a vitamin K-dependent plasma glycoprotein that, once activated, converts factor X to its active form as part of the intrinsic coagulation pathway. Deficiency in Factor IX causes hemophilia B, making the protein central to bleeding-disorder diagnostics and to gene-therapy research aimed at restoring coagulation function.
Catalog highlights and purchasing considerations
About the Biocompare Factor IX catalog
The Biocompare antibody search tool lists anti-Factor IX antibodies from a range of suppliers, spanning polyclonal and monoclonal formats validated across multiple applications. ELISA, western blot, and immunohistochemistry are the most common validated applications among these products.
Considerations when choosing a Factor IX antibody for research
Confirm that the antibody's intended target is accurate, as many genes carry synonym symbols that can create ambiguity across suppliers. Specificity should be verified against the immunogen sequence or region listed on the product datasheet, since antibodies raised against different epitopes of the same protein can behave differently across applications. Beyond specificity, several target-related attributes can affect antibody binding, including subcellular location, extracellular and cytoplasmic domain boundaries for membrane-associated targets, tissue specificity, post-translational modifications, and the presence of additional isoforms or disease-associated variants. In parallel, antibody-specific selection criteria include clonality (monoclonal versus polyclonal), host species, species reactivity, and the choice of conjugate or label suited to the intended detection method. Supplier-provided validation data, such as western blot bands at the expected molecular weight, immunohistochemistry staining patterns consistent with known tissue distribution, or knockout and knockdown controls, is widely regarded as the most reliable final check before purchase.