Anti-MS4A2 antibodies are used in the immunodetection of the protein membrane spanning 4-domains A2. In humans, the canonical protein has a reported length of 244 amino acid residues and a mass of 26.5 kDa. Its subcellular localization is in the membrane. It is notably expressed in the tonsil, skin, and bone marrow. A member of the MS4A protein family, MS4A2 is a high affinity receptor that binds to the Fc region of immunoglobulins epsilon. Post-translational modifications have been described, including phosphorylation.
The MS4A2 marker can be used to identify Tissue Resident Mucosal Type Mast Cells, Connective Tissue Type Mast Cells, and Mast Cells.* Synonyms for this target antigen include ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, high affinity immunoglobulin epsilon receptor subunit beta, and APY. MS4A2 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Some MS4A2 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunofluorescence is also a common application.
*HuBMAP Human Reference Atlas v1.4