Anti-PKP1 antibodies are used in the immunodetection of the protein plakophilin 1. In humans, the canonical protein has a reported length of 747 amino acid residues and a mass of 82.9 kDa. Its subcellular localization is in the nucleus and cell junctions. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the skin, oral mucosa, esophagus, cervix, and cerebral cortex. A member of the Beta-catenin protein family, PKP1 is believed to play a role in junctional plaques. The PKP1 gene has been associated with the disease, Ectodermal dysplasia-skin fragility syndrome. Synonyms for this target antigen include EDSFS, band 6 protein, and B6P. PKP1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of PKP1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Flow Cytometry, Immunofluorescence, and Immunohistochemistry are also common applications.