Anti-CD1B antibodies are used in the immunodetection of the protein CD1b molecule. In humans, the canonical protein has a reported length of 333 amino acid residues and a mass of 36.9 kDa. Its subcellular localization is in the lysosomes and cell membrane. Up to 2 different isoforms have been reported for this protein. It is noted to be expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues. CD1B is reported to be an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
The CD1B marker can be used to identify Double-Positive ?ß Thymocytes.* Synonyms for this target antigen include CD1A, T-cell surface glycoprotein CD1b, CD1B antigen, b polypeptide, cortical thymocyte antigen CD1B, and CD1. CD1B gene orthologs have been reported in the mouse, rat and chimpanzee species. A number of CD1b antibodies have been mentioned in research publications and have associated citations. These antibodies are most commonly used in Flow Cytometry experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4