Anti-MOG antibodies are used in the immunodetection of the protein myelin oligodendrocyte glycoprotein. In humans, the canonical protein has a reported length of 247 amino acid residues and a mass of 28.2 kDa. Up to 13 different isoforms have been reported for this protein. It is notably expressed in the small intestine, cerebral cortex, cerebellum, and caudate. A member of the BTN/MOG protein family, MOG is known to mediate homophilic cell-cell adhesion (By similarity). Post-translational modifications have been described, including glycosylation. The MOG marker can be used to identify Oligodendrocytes.* Synonyms for this target antigen include BTNL11, MOGIG2, NRCLP7, MOG AluA, MOG AluB, MOG Ig-AluB, MOG alpha-5, and BTN6. MOG gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4