Anti-LPO antibodies are used in the immunodetection of the protein lactoperoxidase. In humans, the canonical protein has a reported length of 712 amino acid residues and a mass of 80.3 kDa. Its subcellular localization is in the cytoplasm and is secreted. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the salivary gland. A member of the Peroxidase protein family, LPO is reported to be a heme-containing oxidoreductase, which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (By similarity). Post-translational modifications have been described, including glycosylation.
The LPO marker can be used to identify Bronchus Submucosal Gland Myoepithelial Cells Serous Secreting Cells, Bronchus Serous Cells, and Trachea Serous Cells.* Synonyms for this target antigen include SPO and salivary peroxidase. LPO gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. A number of LPO antibodies have been mentioned in research publications and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4