Anti-Gelsolin antibodies are used in the immunodetection of the protein encoded by the GSN gene. In humans, the canonical protein has a reported length of 782 amino acid residues and a mass of 85.7 kDa. Its subcellular localization is in the cytoplasm and is also secreted. A member of the Villin/gelsolin protein family, it is known to be involved with nervous system development. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include AGEL, actin-depolymerizing factor, brevin, epididymis secretory sperm binding protein, and ADF.