Anti-GNS antibodies are used in the immunodetection of the protein glucosamine (N-acetyl)-6-sulfatase. In humans, the canonical protein has a reported length of 552 amino acid residues and a mass of 62.1 kDa. Its subcellular localization is in the lysosomes. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. It is a member of the Sulfatase protein family. Post-translational modifications have been described, including protein cleavage and glycosylation. The GNS gene has been associated with the disease, Mucopolysaccharidosis. Synonyms for this target antigen include N-acetylglucosamine-6-sulfatase, glucosamine -6-sulfatase, and G6S. GNS gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some GNS antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.