Anti-DR1 antibodies are used in the immunodetection of the protein down-regulator of transcription 1. In humans, the canonical protein has a reported length of 176 amino acid residues and a mass of 19.4 kDa. Its subcellular localization is in the nucleus. It is notably widely expressed in many tissue types. A member of the NC2 beta/DR1 protein family, DR1 is known to be involved with chromatin remodeling and the regulation of transcription. Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include NC2-BETA, NC2B, NCB2, protein Dr1, TATA-binding protein-associated phosphoprotein, and NC2. DR1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some DR1 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.