Anti-TMEM135 antibodies are used in the immunodetection of the protein transmembrane protein 135. In humans, the canonical protein has a reported length of 458 amino acid residues and a mass of 52.3 kDa. Its subcellular localization is in the mitochondria. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of a the TMEM135 protein family, TMEM135 is known to be involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. Synonyms for this target antigen include peroxisomal membrane protein 52.