Anti-SPG7 antibodies are used in the immunodetection of the protein SPG7 matrix AAA peptidase subunit, paraplegin. In humans, the canonical protein has a reported length of 795 amino acid residues and a mass of 88.2 kDa. Its subcellular localization is in the mitochondria. Up to 2 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. A member of the AAA ATPase protein family; Peptidase M41 protein family, SPG7 is known to be involved with nervous system development and proteolysis. Synonyms for this target antigen include CMAR, PGN, SPG5C, paraplegin, SPG7, paraplegin matrix AAA peptidase subunit, and CAR. SPG7 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of SPG7 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Flow Cytometry, Immunofluorescence, and Immunohistochemistry are also common applications.