Anti-CNDP1 antibodies are used in the immunodetection of the protein carnosine dipeptidase 1. In humans, the canonical protein has a reported length of 507 amino acid residues and a mass of 56.7 kDa. It has been described to be a secreted protein. It is notably expressed in the heart muscle, cerebral cortex, and cerebellum. A member of the Peptidase M20A protein family, CNDP1 is known to catalyze the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-3-methyl-histidine). Post-translational modifications have been described, including glycosylation.
The CNDP1 marker can be used to identify Thalamus Oligodendrocyte Precursor Cells and Brain Oligodendrocytes.* Synonyms for this target antigen include CNDP dipeptidase 1, carnosinase 1, carnosine dipeptidase 1 (metallopeptidase M20 family), glutamate carboxypeptidase-like protein 2, serum carnosinase, and beta-Ala-His dipeptidase. CNDP1 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4