Anti-OPTC antibodies are used in the immunodetection of the protein opticin. In humans, the canonical protein has a reported length of 332 amino acid residues and a mass of 37.3 kDa. Its subcellular localization is in the extracellular matrix and is secreted. It is reported to be expressed in cartilage and synovial membranes. A member of the Small leucine-rich proteoglycan (SLRP) protein family, optc is reported to inhibit angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Post-translational modifications have been described, including O-glycosylation, protein cleavage and sulfation. Synonyms for this target antigen include OPT and oculoglycan. OPTC gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. Some optc antibodies may have been used in research and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.