Anti-TGM2 antibodies are used in the immunodetection of the protein transglutaminase 2. In humans, the canonical protein has a reported length of 687 amino acid residues and a mass of 77.3 kDa. Its subcellular localization is in the cell membrane, nucleus, extracellular matrix, mitochondria, and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the placenta, lung, heart muscle, endometrium, and colon. A member of the Transglutaminase protein family, TGM2 is reported to be a calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Synonyms for this target antigen include TG(C), TGC, hTG2, tTG, protein-glutamine gamma-glutamyltransferase 2, and G(h). Over 300 citations in the literature describe the use of TGM2 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.