Anti-PPCS antibodies are used in the immunodetection of the protein phosphopantothenoylcysteine synthetase. In humans, the canonical protein has a reported length of 311 amino acid residues and a mass of 34 kDa. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the PPC synthetase protein family, ppcs is known to catalyze the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. The PPCS gene has been associated with the disease, Cardiomyopathy. Synonyms for this target antigen include phosphopantothenate--cysteine ligase and PPC synthetase. PPCS gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.