Anti-HELZ antibodies are used in the immunodetection of the protein helicase with zinc finger. In humans, the canonical protein has a reported length of 1942 amino acid residues and a mass of 219 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in thymus and brain. A member of the DNA2/NAM7 helicase protein family, Helz is believed to act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. Synonyms for this target antigen include DRHC, HUMORF5, probable helicase with zinc finger domain, down-regulated in human cancers protein, helicase with zinc finger domain, and DHRC. HELZ gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Immunofluorescence is the most common application for the Helz antibodies listed below. Flow Cytometry, Western Blot, and Immunohistochemistry are also common applications.