Anti-Hmgb2 antibodies are used in the immunodetection of the protein high mobility group box 2. In humans, the canonical protein has a reported length of 209 amino acid residues and a mass of 24 kDa. Its subcellular localization is in the nucleus, cytoplasm, and is also secreted. It is reported to be expressed in gastric and intestinal tissues. A member of the HMGB protein family, it is known to be involved with the cellular response to lipopolysaccharides and chromatin organization. Post-translational modifications have been described, including acetylation. Synonyms for this target antigen include high mobility group protein B2, HMG-2, high mobility group protein 2, high-mobility group (nonhistone chromosomal) protein 2, and HMG2.