Anti-FLG antibodies are used in the immunodetection of the protein filaggrin. In humans, the canonical protein has a reported length of 4061 amino acid residues and a mass of 435.2 kDa. Its subcellular localization is in the cytoplasm. It is notably expressed in the vagina, tonsil, skin, oral mucosa, and esophagus. A member of the S100-fused protein family, FLG is known to be involved with keratinocyte differentiation. Post-translational modifications have been described, including protein cleavage and phosphorylation. The FLG marker can be used to identify Corneocyte Keratinocytes.* Synonyms for this target antigen include FLG-1, FLG1, epidermal filaggrin, and ATOD2. FLG gene orthologs have been reported in the mouse, rat and chimpanzee species. Over 100 citations in the literature describe the use of Flg antibodies in research. Immunohistochemistry is a widely used application for these antibodies. In addition, Immunofluorescence is also a common application.
*HuBMAP Human Reference Atlas v1.4