Anti-USP53 antibodies are used in the immunodetection of the protein ubiquitin specific peptidase 53. In humans, the canonical protein has a reported length of 1073 amino acid residues and a mass of 120.8 kDa. Its subcellular localization is in the cell junctions. It is reported to be highly expressed in skeletal muscle and heart. A member of the Peptidase C19 protein family, USP53 is known to be involved with the apoptotic pathway and protein deubiquitination. The USP53 gene has been associated with the disease, Cholestasis. Synonyms for this target antigen include inactive ubiquitin carboxyl-terminal hydrolase 53, inactive ubiquitin-specific peptidase 53, ubiquitin specific protease 53, ubiquitin specific proteinase 53, and PFIC7. USP53 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of USP53 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.