Anti-USP28 antibodies are used in the immunodetection of the protein ubiquitin specific peptidase 28. In humans, the canonical protein has a reported length of 1077 amino acid residues and a mass of 122.5 kDa. Its subcellular localization is in the nucleus. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Peptidase C19 protein family, USP28 is known to be involved with cell proliferation and DNA damage pathways. Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include deubiquitinating enzyme 28, ubiquitin thioesterase 28, ubiquitin thiolesterase 28, ubiquitin-specific-processing protease 28, and ubiquitin carboxyl-terminal hydrolase 28. USP28 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 50 citations in the literature describe the use of USP28 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.