Anti-Semaphorin 6D antibodies are used in the immunodetection of the protein encoded by the SEMA6D gene. In humans, the canonical protein has a reported length of 1073 amino acid residues and a mass of 119.9 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Alternative splicing is reported to yield 8 different isoforms for this protein. A member of the Semaphorin protein family, it is known to be involved with the regulation of cell migration. Post-translational modifications have been described, including glycosylation. Other names for this target antigen include sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D.