Anti-PRSS12 antibodies are used in the immunodetection of the protein serine protease 12. In humans, the canonical protein has a reported length of 875 amino acid residues and a mass of 97.1 kDa. It has been described to be a secreted protein. A member of the Peptidase S1 protein family, PRSS12 is reported to play a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. Post-translational modifications have been described, including glycosylation.
The PRSS12 marker can be used to identify Midbrain-Derived Inhibitory Neurons.* Synonyms for this target antigen include BSSP3, MRT1, neurotrypsin, brain-specific serine protease 3, leydin, and BSSP-3. PRSS12 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Western Blot is the most common application for the PRSS12 antibodies listed below. ELISA, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4