Anti-SETD3 antibodies are used in the immunodetection of the protein SET domain containing 3, actin N3(tau)-histidine methyltransferase. In humans, the canonical protein has a reported length of 594 amino acid residues and a mass of 67.3 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the SETD3 actin-histidine methyltransferase protein family, SETD3 is reported to be a protein-histidine n-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Synonyms for this target antigen include SET domain-containing protein 3, histone-lysine N-methyltransferase setd3, protein-L-histidine N-tele-methyltransferase, and actin-histidine N-methyltransferase. SETD3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of SETD3 antibodies have been mentioned in research publications and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.