Anti-Filamin B antibodies are used in the immunodetection of the protein encoded by the FLNB gene. In humans, the canonical protein has a reported length of 2602 amino acid residues and a mass of 278.2 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 9 different isoforms for this protein. It is ubiquitously expressed across many tissue types. A member of the Filamin protein family, it is known to be involved with cytoskeleton organization and signal transduction pathways. Post-translational modifications have been described, including ubiquitination. Other names for this target antigen include ABP-278 and ABP-280.