Anti-periaxin antibodies are used in the immunodetection of the protein encoded by the PRX gene. In humans, the canonical protein has a reported length of 1461 amino acid residues and a mass of 154.9 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is notably expressed in spinal cord. A member of the Periaxin protein family, it is reported to be a scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells.