Anti-KRT6C antibodies are used in the immunodetection of the protein keratin 6C. In humans, the canonical protein has a reported length of 564 amino acid residues and a mass of 60 kDa. It is notably expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath. A member of the Intermediate filament protein family, KRT6C is known to be involved with cytoskeleton organization. The KRT6C gene has been associated with the disease, Palmoplantar keratoderma. Synonyms for this target antigen include CK-6C, CK-6E, K6C, cytokeratin-6C, cytokeratin-6E, keratin 6C, type II, and keratin, type II cytoskeletal 6C. Over 220 citations in the literature describe the use of KRT6C antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.