Anti-FRMD7 antibodies are used in the immunodetection of the protein FERM domain containing 7. In humans, the canonical protein has a reported length of 714 amino acid residues and a mass of 81.6 kDa. Its subcellular localization is in the cell projections. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in the liver, kidney, pancreas and at low levels in the brain and heart. FRMD7 is reported to play a role in neurite development, may be through the activation of the GTPase RAC1.
The FRMD7 marker can be used to identify Brain Splatter Neurons.* Synonyms for this target antigen include FERM domain-containing protein 7. FRMD7 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of FRMD7 antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. In addition, Immunofluorescence is also a common application.
*HuBMAP Human Reference Atlas v1.4