Anti-TRIM22 antibodies are used in the immunodetection of the protein tripartite motif containing 22. In humans, the canonical protein has a reported length of 498 amino acid residues and a mass of 56.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. A member of the TRIM/RBCC protein family, TRIM22 is known to be involved with immune response pathways. Post-translational modifications have been described, including ubiquitination.
The TRIM22 marker can be used to identify Deep-Layer Near-Projecting Neurons and Deep-Layer Corticothalamic And 6B Neurons.* Synonyms for this target antigen include RNF94, STAF50, E3 ubiquitin-protein ligase TRIM22, 50 kDa-stimulated trans-acting factor, RING finger protein 94, and GPSTAF50. A number of TRIM22 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4