Anti-RCF1a antibodies are used in antigen-specific immunodetection in biological samples. The target RCF1a is a known alias name of the protein HIG1 hypoxia inducible domain family member 1A, encoded by the HIGD1A gene in humans. This 93-amino acid residue protein is reported to be a proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. It is localized to the mitochondria of the cell. It is reported to be expressed in many tissues, such as the appendix and parathyroid gland. Other synonyms for RCF1a include HIG1 and HIG1 domain family member 1A, mitochondrial.