Brefeldin A Gives Good Results

October 04, 2021

BlueskyReddit
Stanford University
Biology
Graduate Student

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Company:

Sigma

Product Name:

Brefeldin A

Catalog Number:

B6542-5MG

Brefeldin A is a compound that inhibits COPI-mediated vessicle transport from ER to Golgi, thereby inhibiting classical secretory pathway. Treating mouse primary hepatocytes with 1ug/ml Brefeldin A greatly reduces ApoB48 secretion.

Experimental Design and Results Summary

Application

Chemical inhibition of classical secretory pathway

Starting Material

Mouse primary hepatocytes

Tips

Aliquote the compound upon arrival.

Results Summary

Brefeldin A is a compound that inhibits COPI-mediated vessicle transport from ER to Golgi, thereby inhibiting classical secretory pathway. Treating mouse primary hepatocytes with 1ug/ml Brefeldin A greatly reduces ApoB48 secretion.

DOI or PMID #

N/A

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The Bottom Line

This is a great compound that inhibits COPI-mediated vessicle transport from ER to Golgi, thereby inhibiting classical secretory pathway. Treating mouse primary hepatocytes with 1ug/ml Brefeldin A greatly reduces ApoB48 secretion.

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