Trimethyl Histone H3 Antibody from Sigma Is Very Good

Orthopedic surgery
Johns Hopkins University School of Medicine
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

MilliporeSigma

Product Name:

Anti-trimethyl Histone H3 (Lys27) Antibody, clone 18E9.1

Catalog Number:

05-1951

Clone Number:

18E9.1

My research focuses on molecular mechanisms of axon growth and guidance during neural development and axon regeneration after injuries to the central nervous system or peripheral nerves. For this western blot experiment, I want to detect the expression of H3K27me3 in mouse dorsal root ganglion.

Experimental Design and Results Summary

Applications

Western Blot

Sample

Mouse dorsal root ganglion

Primary Incubation

1:5000, overnight at 4°C

Blocking Agent

TBST (0.1%) containing 5% blotting-grade blocker

Secondary Incubation

1:2000, 1 hr at room temperature

Tertiary Incubation

N/A

Detection

KwikQuantTM Imager

Results Summary

There are two bands but only the lower one is H3K27me3 (MW 17).

DOI or PMID #

N/A

Additional Notes

N/A

Related Categories

Image Gallery

Summary

The Good

The antibody is ok

The Bad

There is an unspecific band

The Bottom Line

It is ok for detecting the expression of H3K27me3.

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