iMLayer Matrix Vapor Deposition System from Shimadzu

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ItemiMLayer Matrix Vapor Deposition System
CompanyShimadzu
Price Get Pricing Get Quote for this Product
Catalog NumberiMLayer
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Shimadzu

7102 Riverwood Drive

Columbia, Maryland

United States

Phone: 1-800-477-1227
1-800-477-1227
1-410-381-1222

Company Profile

Website: https://www.ssi.shimadzu.com/

(1) Dry Deposition Strategies for MALDI-MS Imaging: Principles, Advances and Emerging ApplicationsAnal Sci AdvApril 22, 2026Toufik Mahamdi, Oscar Yanesdeliver reproducible, uniform and high‐quality matrix coatings for MALDI–MSI (Table 1). Among them, iMLayer (Shimadzu, Japan) is one of the most widely adopted platforms. It employs an automated vacuum sublimation

(2) SMASH Imaging: A Serial Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Strategy for High-Resolution Imaging Facilitates Dual-Polarity and MS2 Spatial Lipidomics on a Single Tissue SectionAnalytical ChemistryApril 7, 2026Haruki Uchino, Hiroshi Tsugawa, Makoto AritaTechnologies, NC, USA) (Table S1). The DHB matrix was applied to the brain tissue by sublimation using an iMLayer (Shimadzu, Kyoto, Japan). For matrix deposition, DHB (300 mg) was sublimated at 250 °C under vacuum

(3) An integrative spatial multi-omic workflow for unified analysis of tumor tissueCell Reports MethodsFebruary 23, 2026Jurgen Kriel, Joel J.D. Moffet, Tianyao Lu, Oluwaseun E. Fatunla, Vinod K. Narayana, Adam Valkovic, Ana Maluenda, Malcolm J. McConville, Ellen Tsui, James R. Whittle, et al.α-cyano-4-hydroxycinnamic acid (CHCA, P# C2020, Sigma-Aldrich) by sublimation (0.7 μm thickness at 250°C) using iMLayer (Shimadzu, Japan), followed by CHCA matrix spraying using iMLayer AERO (Shimadzu, Japan) to recrystallize

(4) Sex-Specific Metabolic Footprint of Ketogenic Diet in C57BL/6J MiceBiomedicinesFebruary 19, 2026Marko Sablić, Viktoria Čurila, Barbara Viljetić, Lovro Mihajlović, Zeljka Korade, Károly Mirnics, Irena Labak, Leonarda Murvaj, Senka Blažetić, Vedrana Ivić, et al.matrix α-cyano-4-hydroxycinnamic acid (CHCA) (Sigma-Aldrich, St. Louis, MO, USA) was applied using an iMLayer sublimation device (Shimadzu, Kyoto, Japan) according to the manufacturer’s instructions (10 min sublimation

(5) Exploratory Characterization of Coronary Thrombi by Integrated Mass Spectrometry and Elemental Imaging in Acute Coronary SyndromeCureusFebruary 9, 2026Mayo Wada, Tadayuki Ogawa, Setsu Nishino, Ryota Hashimoto, Masashi Sakuma, Shigeru Toyoda149357, Sigma-Aldrich, St. Louis, MO) was uniformly applied using an automated matrix deposition system (iMLayer, Shimadzu, Kyoto, Japan). MALDI mass spectrometry imaging (MALDI-MSI) was performed using an iMScope

(6) Spatiotemporal Dynamics of Polyphenolic Compounds in Musa spp. during Ripening Revealed by Mass Spectrometry ImagingJournal of Agricultural and Food ChemistryJanuary 14, 2026Hiroko Shinoda, Shiho Ishimoto, Eiichiro Fukusaki, Shuichi Shimmaonto ITO glass containing the frozen sections, which were placed by using a vacuum sublimation system (iMLayer; Shimadzu Corporation, Kyoto, Japan). In the spray method, a mixture of acetonitrile, ultrapure water,

(7) Mycophenolate mofetil reduces the branching of microglial processesMolecular BrainJanuary 11, 2026Rin-ichiro Teruya, Kentaro Ueda, Takumi Taketomi, Takushi Yamamoto, Naoki Yamashita, Hana Konno, Fuminori Tsuruta− 20 °C and stored at − 80 °C with desiccant in 50 ml tubes. Matrix deposition was performed using iMLayer (Shimadzu, Kyoto, Japan). 9-aminoacridine (9-AA) (Merck KGaA, Darmstadt, Germany) was heated at 250

(8) Assessment of Tumor Margin and Heterogeneity of Colorectal Cancer Using Imaging Mass Spectrometry and Image SegmentationCancers (Basel)January 3, 2026Bojan Trogrlić, Ana Bednjanić, Borna Kovačić, Zrinka Požgain, Dario Mandić, Magdalena Kratofil, Jasmina Rajc, Željko Debeljak, Ilijan Tomašrecrystallization of the MALDI matrix on the ITO slide containing tissue sections were performed using the iMLayer (Shimadzu, Kyoto, Japan) device for automated matrix application. For the positive mode, 0.3 g of DHB

(9) Resolving agrochemical penetration in wheat leaves with secondary ion mass spectrometry imaging and depth profilingAnalytical and Bioanalytical ChemistryNovember 1, 2025Akhila Ajith, Sadia Sheraz, Aline Xavier de Souza, Drupad K. Trivedi, Jean-Yves Mugnier, Giles N. Johnson, Phillip J. Milnes, Nicholas P. Lockyerthe leaf cryo-sections were sublimated with α-cyano-4-hydroxycinnamic acid (CHCA) using a Shimadzu iMLayer matrix vapour deposition system. The CHCA matrix was selected as found appropriate in previous studies

(10) On-tissue derivatization for mass spectrometry imaging reveals the distribution of short chain fatty acids in murine digestive tractFront Cell Infect MicrobiolOctober 3, 2025Kaoru Nakagawa, Mami Okamoto, Masako Nishida, Kenta Terashima, Manami Kobayashi, Kanae Teramoto, Akiko KuboCreos. Tokyo, Japan), or CHCA (300 mg) was sublimated at 250 °C under vacuum (5 × 10−2 Pa) using the iMLayer™ (Shimadzu, Kyoto, Japan), a matrix deposition device that can control the temperature and calculate

(11) Single-cell metabolite annotation by tandem mass spectrometry imaging and ab initio molecular dynamics-based fragmentationRSC AdvancesSeptember 11, 2025Mateo Topalović, Ivana Marković, Vlatka Periša, Maja Lukić, Ema Pavičić, Iva Lukić, Stefan Mrđenović, Igor Lukačević, Željko Debeljakmatrix, α-cyano-4-hydroxycinnamic acid (CHCA; Merck, Germany), was then deposited on the slide using an iMLayer sublimation device (Shimadzu, Japan) for 10 minutes. It is worth mentioning that very recently, new

(12) Evaluation of Stemona collinsiae root extracts for topical cockroach control: adulticidal, nymphicidal, and chemical distribution analysisToxicon: XJune 1, 2025Aurapa Sakulpanich, Anon Phayakkaphon, Korawan Ounklong, Jinnaphat Sommanat, Yudthana Samung, Raweewan Srisawat, Jiraporn Ruangsittichaiautomatically sprayed with α-Cyano-4-hydroxycinnamic acid (CHCA) (Sigma Aldrich, Darmstadt, Germany) using the iMLayer (Shimadzu, Japan). The film thickness was controlled at 0.7 μm, with a deposition time of 8 min and

(13) Spatial Neurolipidomics - MALDI Mass Spectrometry Imaging of Lipids in Brain PathologiesJournal of Mass SpectrometryApril 2, 2025Durga Jha, Kaj Blennow, Henrik Zetterberg, Jeffrey N. Savas, Jörg Hanriedersprayer systems, such as the TM or M3+ Sprayer (HTX Technologies), SunCollect Sprayer (Sunchrom), or iMLayer (Shimadzu), along with open-source or even manual airbrush systems. Potential sources of error during

(14) In situ quantification of fungicide residue on wheat leaf surfaces using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging technologyFood Chem XJanuary 6, 2025Xuerui Yang, Mengyao Shi, Minghui Hong, Zhixin Hui, Jiaqi Pan, Guangli Xiu, Lei ZhouA commercial spray gun (Platinum 0.2, Chiyoda Japan Co., Ltd.) and the matrix elevating instrument (iMLayer™ Shimadzu China Co., Ltd) were utilized to apply a uniform coating of the matrix solution onto the sample

(15) Influence of Sulfur Fumigation on Angelicae Dahuricae Radix: Insights from Chemical Profiles, MALDI-MSI and Anti-Inflammatory ActivitiesMoleculesDecember 25, 2024Changshun Wang, Yongli Liu, Xiaolei Wang, Zhenhe Chen, Zhenxia Zhao, Huizhu Sun, Jian Su, Ding Zhaoglass slide was fixed to the holder and transferred to an automatic matrix sublimation instrument (iMLayer, Shimadzu, Kyoto, Japan) for matrix application. α-Cyano-4-hydroxycinnamic acid (CHCA) was deposited

(16) Imaging Lipidomics and Metallomics of Brown Rice Cultivars Used for Sake ProductionMass Spectrom (Tokyo)December 17, 2024Eliza Farestiani, Yoshihiro Tamada, Koji Okuda, Eiichiro Fukusaki, Shuichi Shimmadeposited on ITO glass loaded with rice sections by sublimation method using matrix vapor deposition device iMLayer™ (Shimadzu, Kyoto, Japan) with the following conditions: CHCA with a thickness of 0.7 μm at 180°C; DHB

(17) Combination of Probe Electrospray Ionization Mass Spectrometry and Mass Spectrometry Imaging to Analyze Plant Alkaloids in Narcissus tazettaMass Spectrom (Tokyo)December 10, 2024Kaoru Nakagawa, Tetsuo Iida, Manami Kobayashi, Shuichi Shimmasilica gel for 10 min. After dehydration, the samples were coated with CHCA via vapor deposition using iMLayer (Shimadzu, Kyoto, Japan) at a thickness of 0.7 μm. Fig. 2. Locations of Narcissus tazetta sections.

(18) The good, the bad, and the unknown nature of decreased GD3 synthase expressionFrontiers in Molecular NeuroscienceNovember 22, 2024Borna Puljko, Josip Grbavac, Vinka Potočki, Katarina Ilic, Barbara Viljetić, Svjetlana Kalanj-Bognar, Marija Heffer, Željko Debeljak, Senka Blažetić, Kristina Mlinac-JerkovicTissue sections were mounted on ITO slides. The matrix (9-aminoacridine) was applied to samples using iMLayer device (Shimadzu, Kyoto, Japan) which included a 15 min sublimation at 180°C, followed by 5 min recrystallization

(19) Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibitionJournal of Clinical InvestigationNovember 19, 2024Kristen E. Kay, Juyeun Lee, Ellen S. Hong, Julia Beilis, Sahil Dayal, Emily R. Wesley, Sofia Mitchell, Sabrina Z. Wang, Daniel J. Silver, Josephine Volovetz, et al.was purchased from MilliporeSigma. Matrix deposition was performed by 2-step deposition method using iMLayer for sublimation and iMLayer AERO (Shimadzu) for matrix spraying. The thickness of the vapor-deposited

(20) Tissue derivatization for visualizing lactate and pyruvate in mouse testis tissues using matrix-assisted laser desorption/ionization-mass spectrometry imagingAnalytical and Bioanalytical ChemistryNovember 1, 2024Erika Nagano, Kazuki Odake, Shuichi Shimmacomplete the derivatization reaction on the tissue. MALDI matrix supply A vacuum evaporation system (iMLayer™; Shimadzu Corporation, Kyoto, Japan) was used to deposit 1,5-DAN on each ITO glass loaded with testicular

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