Human Chitinase 3-like 1/YKL-40 DuoSet ELISA DY2599 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemHuman Chitinase 3-like 1/YKL-40 DuoSet ELISA
CompanyR&D Systems, a Bio-Techne Brand
Price $890.00Supplier Page View Company Product Page
Catalog NumberDY2599
Quantity1 Kit (for 15 Plates)
ApplicationsELISA
Detection Range31.20 - 2000 pg/mL
ReactivityHuman
Detection TargetChitinase 3-like 1/YKL-40
StorageStore the unopened product at 2 - 8 °C. Do not use past expiration date
NCBI Full Gene Namechitinase 3 like 1
NCBI Gene AliasesASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YK-40, YKL-40, YKL40, YYL-40, hCGP-39

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Inhibition of p38α MAPK increases short-term astrocyte reactivity: the exploratory VIP trial in early Alzheimer’s diseaseJournal of NeuroinflammationNovember 24, 2025Dominique Gouilly, Alexandre Da-Costa, Agathe Vrillon, Aurélie Pistono, Marie Goubeaud, Elsa Bertrand, Johanne Germain, Nadéra Ainaoui, Stéphanie Bras, Hélène Catala, et al.levels were measured using a commercial Elisa assay from R&D system (sTREM-2: # DY1828-05, YKL-40 # DY2599). IL-6 and IL-10 levels were measured using the Human Cytokine Multiplex Panel A from R&D System (#QC11).

(2) APOE ε4 potentiates tau related reactive astrogliosis assessed by cerebrospinal fluid YKL40 in Alzheimer’s diseaseCommunications MedicineNovember 20, 2025Lydia Trudel, Joseph Therriault, Arthur C. Macedo, Marcel S. Woo, Nesrine Rahmouni, Étienne Aumont, Stijn Servaes, Seyyed Ali Hosseini, João Pedro Ferrari-Souza, Bruna Bellaver, et al.quantified using a commercially available ELISA assay (R&D Systems, Minneapolis, MN, USA, catalog #DY2599)31. Neuroimaging Study participants underwent magnetic resonance imaging (MRI) using 3D T1-weighted

(3) Evaluating the Influence of CHI3L1 and PI3 Methylation in Allergic and Nonallergic AsthmaBiomoleculesSeptember 25, 2025Selene Baos, Lucía Cremades-Jimeno, María Ángeles de Pedro, María López-Ramos, Rubén Fernández-Santamaría, Cristina Rosales-Ariza, Joaquín Quiralte, Fernando Florido, Nicolás González-Mangado, María Jesús Rodríguez-Nieto, et al.Serum levels of CHI3L1 and PI3 were measured using the human chitinase-3-like 1 DuoSet ELISA (Cat# DY2599) and the Human Trappin-2/Elafin DuoSet ELISA (Cat# DY1747) (R&D Systems, Minneapolis, MN, USA). 2.6.

(4) Levels of Exhaled Fraction of Nitric Oxide (FeNO) and Type 2 Biomarkers in Individuals Naturally Exposed to Helminth Parasites in a Tropical RegionInternational Journal of Molecular SciencesAugust 28, 2025Maria M. De Vivero, Randy Reina, Jonathan Ramírez, Josefina Zakzuk, Jose Miguel Escamilla Gil, Bayron Zelaya, Lucila Teresa Florez de Arco, Daniel P. Potaczek, Luis Caraballo, Nathalie Acevedopreviously described [75]. YKL-40 measurement was performed with a commercially ELISA Duoset kit (Cat. DY2599 R&D Systems, Minneapolis, MN, USA) following the manufacturer’s instructions and the levels were expressed

(5) Dissection of blood-brain barrier dysfunction through CSF PDGFRβ and amyloid, tau, neuroinflammation, and synaptic CSF biomarkers in neurodegenerative disordersEBioMedicineMay 1, 2025Vrillon A, Ashton NJ, Bouaziz-Amar E, Mouton-Liger F, Cognat E, Dumurgier J, Lilamand M, Karikari TK, Prevot V, Zetterberg H, et al.(18,000–24 pg/mL). CSF YKL-40 levels were measured using a commercial ELISA kit from R&D System (Kit #DY2599, Minneapolis, MN, USA). CSF soluble triggering receptor expressed on myeloid cells 2 (sTREM 2) was measured

(6) The sEVs miR-487a/Notch2/GATA3 axis promotes osteosarcoma lung metastasis by inducing macrophage polarization toward the M2-subtypeCancer cell internationalAugust 31, 2024Wang P, Yang L, Dong J, Liu W, Xie F, Lu Y, Li W.and CD163.ELISA was performed using a human Arg-1 (#EK1316, Multi Sciences, Hangzhou, China), Ym1 (#DY2599, R&D system, USA), CD163 (#DC1630, R&D system), iNOS (#CB11694-Hu, Coibo Bio, Shanghai, China) and CD86

(7) Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodiesAlzheimer's Research & TherapyJuly 3, 2024Agathe Vrillon, Olivier Bousiges, Karl Götze, Catherine Demuynck, Candice Muller, Alix Ravier, Benoît Schorr, Nathalie Philippi, Claire Hourregue, Emmanuel Cognat, et al.YKL-40 levels were measured using commercial ELISA kits from R&D System (respectively, #DY1828-05 and #DY2599), both validated for plasma measurements. Samples were run blinded in duplicates. Intra- and inter-coefficients

(8) Translocator protein (TSPO) genotype does not change cerebrospinal fluid levels of glial activation, axonal and synaptic damage markers in early Alzheimer’s diseaseNeuroImage: ClinicalMay 31, 2024Dominique Gouilly, Agathe Vrillon, Elsa Bertrand, Marie Goubeaud, Hélène Catala, Johanne Germain, Nadéra Ainaoui, Marie Rafiq, Leonor Nogueira, François Mouton-Liger, et al.sTREM2 levels were measured using commercial Elisa assay from R&D system (sTREM-2: # DY1828-05, YKL-40 # DY2599). IL-6 and IL10 levels were measured using the Human Cytokine Multiplex Panel A from R&D System (#QC11).

(9) Real life data: follow-up assessment on Spanish Gaucher disease patients treated with eliglustat. TRAZELGA projectOrphanet J Rare DisDecember 15, 2023Irene Serrano-Gonzalo, Laura López de Frutos, Carlos Lahoz-Gil, Francisco Delgado-Mateos, María Ángeles Fernández-Galán, Montserrat Morales-Conejo, María Victoria Calle-Gordo, Daiana Ibarretxe-Gerediaga, Andrés Madinaveitia-Ochoa, Antonio Albarracin-Arraigosa, et al.hepcidin and lipocalin-2 were analyzed by immunoassay according to the manufacturer's instructions (DY394, DY2599, DY1183, DY8307 and DY1757, respectively, R&D Systems Europe, Ltd). Finally, GluSph concentration was

(10) Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE studyAlzheimer's Research & TherapyJanuary 12, 2023Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Carl-Christian Kolbe, Steffen Wolfsgruber, Francesco Santarelli, Lisa M. Häsler, Róisín McManus, Christina Ising, et al.2.50.0–16.5,Singleplex,DY850,6 "R&D Systems, Inc.",Colorimetric,YKL-40,1.2 ± 1.80.0–19.4,Singleplex,DY2599,200 IL-6,1.9 ± 1.70.0–10.0,Singleplex,Quanterix Corp.,Digital ELISA (SIMOA),101622,5 Quanterix Corp.,Digital

(11) Anti-Chi3L1 antibody suppresses lung tumor growth and metastasis through inhibition of M2 polarizationMolecular oncologyJune 1, 2022Yu JE, Yeo IJ, Son DJ, Yun J, Han SB, Hong JT.Chi3L1 in mouse serum, human serum, and culture supernatants were measured by ELISA kit (#DY2649, #DY2599, R&D System Inc.). Concentration of mouse plasminogen and human plasminogen in human serum and culture

(12) A â€˜Multiomicâ€™ Approach of Saliva Metabolomics, Microbiota, and Serum Biomarkers to Assess the Need of Hospitalization in Coronavirus Disease 2019Gastro Hep AdvancesFebruary 7, 2022Chiara Pozzi, Riccardo Levi, Daniele Braga, Francesco Carli, Abbass Darwich, Ilaria Spadoni, Bianca Oresta, Carola Conca Dioguardi, Clelia Peano, Leonardo Ubaldi, et al.variability from 8% to 10%. CHI3L1 ELISA Human CHI3L1 levels were measured using the DuoSet ELISA kit (DY2599, R&D systems) as per the manufacturer’s instructions. Blood was always processed in less than 8 hours

(13) Targeting protumor factor chitinase-3-like-1 secreted by Rab37 vesicles for cancer immunotherapyTheranosticsJanuary 1, 2022Yang PS, Yu MH, Hou YC, Chang CP, Lin SC, Kuo IY, Su PC, Cheng HC, Su WC, Shan YS, et al.plasma was detected by a double antibody sandwich ELISA according to the manufacturer's instructions (DY2599, R&D systems). Identically, the mouse CHI3L1 concentration in CM from RAW264.7, BMDM or splenic T cells

(14) Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytomaScientific reportsJune 23, 2021Urbanavičiūtė R, Zabitaitė R, Kriščiukaitis A, Deltuva VP, Skiriutė D.https://www.rndsystems.com/products/human-osteopontin- opn-duoset-elisa_dy1433. 30. Human Chitinase 3-like 1 DuoSet ELISA DY2599: R&D Systems. https://www.rndsystems.com/products/human-chitinase-3- like-1-duoset-elisa_dy2599. 31.

(15) Cerebrospinal Fluid Biomarkers of Myeloid and Glial Cell Activation Are Correlated With Multiple Sclerosis Lesional Inflammatory ActivityFrontiers in neuroscienceJanuary 1, 2021Masvekar R, Phillips J, Komori M, Wu T, Bielekova B.pg/ml BCMA,Homebrew MSD-ECL,R&D Systems (DY193),400 ng/ml and 400 ng/ml,7 pg/ml CHI3L1,Homebrew MSD-ECL,R&D Systems (DY2599),4 μg/ml and 100 ng/ml,41 pg/ml List of kits and antibodies used for biomarker analyses using either

(16) NF-κB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cellsCellular signallingMarch 1, 2020Hübner K, Karwelat D, Pietsch E, Beinborn I, Winterberg S, Bedenbender K, Benedikter BJ, Schmeck B, Vollmeister E.

(17) Aberrant progranulin, YKL-40, cathepsin D and cathepsin S in Gaucher diseaseMolecular Genetics and MetabolismSeptember 1, 2019Yuliya Afinogenova, Jiapeng Ruan, Ruhua Yang, Nathaniel Kleytman, Gregory Pastores, Andrew Lischuk, Pramod K. MistryLevels by ELISA: Serum concentrations of YKL-40 were determined in duplicate using the ELISA kit (DY2599) from R&D systems (Minneapolis, MN) per manufacturer’s instructions after diluting the samples 1:50

(18) Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazoleScientific reportsMay 1, 2019McDonald CR, Weckman AM, Conroy AL, Olwoch P, Natureeba P, Kamya MR, Havlir DV, Dorsey G, Kain KC.

(19) Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational studySleep and BreathingDecember 1, 2018Unnur Dilja Teitsdottir, Erna Sif Arnardottir, Erla Bjornsdottir, Thorarinn Gislason, Petur Henry Petersenplasma samples were measured using a commercially available Sandwich Elisa Duoset from R&D systems (cat. DY2599, Minneapolis, MN). The assays were run in 96-well plates (Nunc 442404, MaxiSorp) using 100 μl of plasma

(20) Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malariaMalaria journalFebruary 15, 2018Conroy AL, Hawkes MT, Elphinstone R, Opoka RO, Namasopo S, Miller C, John CC, Kain KC.

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Human Chitinase 3-like 1/YKL-40 DuoSet ELISA

Chitinase 3-like 1 ELISA

Human Chitinase 3-like 1/YKL-40 DuoSet ELISA from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Human Chitinase 3-like 1/YKL-40 DuoSet ELISA from R&D Systems, a Bio-Techne Brand

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