Human Osteoactivin/GPNMB DuoSet ELISA DY2550 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemHuman Osteoactivin/GPNMB DuoSet ELISA
CompanyR&D Systems, a Bio-Techne Brand
Price $890.00Supplier Page View Company Product Page
Catalog NumberDY2550
Quantity1 Kit (for 15 Plates)
ApplicationsELISA
Detection Range125.00 - 8000 pg/mL
ReactivityHuman
Detection TargetOsteoactivin/GPNMB
StorageStore the unopened product at 2 - 8 °C. Do not use past expiration date
NCBI Full Gene Nameglycoprotein nmb
NCBI Gene AliasesHGFIN, NMB, PLCA3

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodiesmedRxivFebruary 1, 2026Marc Carceles-Cordon, Eliza M. Brody, Masen L. Boucher, Michael D. Gallagher, Robert T. Skrinak, Travis L. Unger, Cooper K. Penner, Adama J. Berndt, Sromona Das, Katie Lam, et al.and brain lysates were quantified using the Human Osteoactivin/GPNMB DuoSet ELISA kit (R&D Systems, #DY2550) in conjunction with the DuoSet ELISA Ancillary Reagent Kit (R&D Systems, #DY008B). CM from PiggyBac-GPNMB

(2) GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosisScience AdvancesDecember 19, 2025Erin C. Bogacki, Gustavo Morrone Parfitt, Adriana Cunha, George Longmore, Selina Wray, Patrick A. Lewis, Susanne HerbstELISA Supernatants for ELISA were prepared by incubating cells with stimuli for ~18 hours. ELISAs for human GPNMB (DY2550, R&D Systems) and mouse GPNMB (DY2330, R&D Systems) were conducted according to the manufacturer’s instructions.

(3) Glycoprotein non-metastatic melanoma protein B is a biomarker of inflammation in individuals with Gaucher disease: relationship to clinico-pathological subtypesOrphanet J Rare DisOctober 28, 2025Sebile Kilavuz, Kerri-Lee Wallom, Ana Catarina Gomes Almeida Augusto Caçote, Aimée Donald, Simona D'Amore, Kathy Page, Chong Yew Tan, Danielle Te Vruchte, Andrea Sturchio, Panagiota Tsitsi, et al.(http://www.RnDSystems.com/ELISADevelopment) using enzyme-linked immunosorbent assay (ELISA) kits (#DY2550 for measuring human gpNMB) from R&D System (Minneapolis, MN). Briefly, plasma samples were diluted 1:100

(4) Elevated levels of cerebrospinal fluid soluble triggering receptor expressed on myeloid cells 2 in multiple system atrophy: a marker of disease-associated microglial activationJournal of Neural TransmissionSeptember 23, 2025Toshiki Maeda, Yasuaki Mizutani, Reiko Ohdake, Ryunosuke Nagao, Kazuya Kawabata, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Hirohisa WatanabesTREM2 and GPNMB in CSF were measured using commercial ELISA kits (ab224881; Abcam, Cambridge, UK, and DY2550; R&D Systems, Minneapolis, MN, USA, respectively). For both sTREM2 and GPNMB measurements, CSF samples

(5) Glycoprotein non-metastatic melanoma protein B is a potential biomarker for arthroplasty aseptic looseningScientific ReportsSeptember 12, 2025Patrik Schadzek, Alexander Derksen, Wiebke Behrens, Maike Kosanke, Oliver Dittrich-Breiholz, Anika Hamm, Kirsten Elger, Yvonne Roger, Ines Yang, Meike Stiesch, et al.sandwich ELISA was performed to analyse the secretion of GPNMB (Human Osteoactivin/GPNMB DuoSet ELISA; DY2550, R&D Systems) or SDC4 (Human Syndecan-4 DuoSet ELISA; DY2918, R&D Systems) according to the manufacturer’s

(6) Increased plasma GPNMB levels in patients with parkinson's disease and cognitive impairmentScientific reportsJuly 1, 2025Qi X, She Z, Shi X, Peng H, Wang L, Ma J, Li X, Liang K, Fan Y, Sun Y, et al.

(7) A High Performing Biomarker Signature for Detecting Early-Stage Pancreatic Ductal Adenocarcinoma in High-Risk IndividualsCancers (Basel)June 2, 2025Norma A. Palma, Aimee L. Lucas, Bryson W. Katona, Alcibiade Athanasiou, Natasha M. Kureshi, Lisa Ford, Thomas Keller, Stephen Weber, Ralph Schiess, Thomas King, et al.glycoprotein non-metastatic melanoma protein B (GPNMB) (Biotechne R&D Systems, Minneapolis, MN, USA #DY2550, RRID:AB3678917), kallikrein related peptidase 10 (KLK10) (Aviva, San Diego, CA, USA #OKDD04348, RRID:AB_3678918),

(8) Malignant mesothelioma-associated inflammatory microenvironment promotes tumor progression via GPNMBJournal of translational medicineApril 18, 2025Belgiovine C, Digifico E, Erreni M, Putignano AR, Mannarino L, Valentino S, Grizzi F, Pasqualini F, Recordati C, Bertola L, et al.supernatants or plasma samples from human subjects, the commercial ELISA kits (R&D Systems DY2330 for mice, DY2550 for human) were used, according to the manufacturer’s instructions. Data were analysed with SoftMax

(9) GPNMB disrupts SNARE complex assembly to maintain bacterial proliferation within macrophagesCellular & Molecular ImmunologyMarch 4, 2025Zhenzhen Yan, Jinghong Han, Zihao Mi, Zhenzhen Wang, Yixuan Fu, Chuan Wang, Ningning Dang, Hong Liu, Furen Zhangand the concentration of GPNMB was measured via human osteoactivin/GPNMB DuoSet ELISA (R&D System, DY2550). Phagocytosis Phagocytosis assays were performed by using a Phagocytosis Assay Kit (IgG FITC) (Cayman,

(10) Glycoprotein non-metastatic melanoma protein B promotes tumor growth and is a biomarker for lymphangioleiomyomatosisEndocrine-Related CancerJune 1, 2024Erin Gibbons, Manisha Taya, Huixing Wu, Samia H Lopa, Joel Moss, Elizabeth P Henske, Francis X McCormack, Stephen R Hammesserum samples or concentrated cell media samples were used. GPNMB was measured using a GPNMB ELISA kit (DY2550, R&D Systems) and DuoSet ELISA Ancillary Reagent Kit 2 (DY008B, R&D Systems). Absorbance was read at

(11) GPNMB Biomarker Levels in GBA1 Carriers with Lewy Body DisordersMovement DisordersJune 1, 2024Eliza M. Brody, Yunji Seo, EunRan Suh, Noor Amari, Whitney G. Hartstone, R. Tyler Skrinak, Hanwen Zhang, Maria E. Diaz‐Ortiz, Daniel Weintraub, Thomas F. Tropea, et al.and CSF samples were tested for GPNMB protein levels using the Human Osteoactivin/GPNMB DuoSet ELISA (DY2550, R&D Systems) according to the manufacturer’s instructions. Plasma and CSF samples were diluted 1:30

(12) GPNMB Promotes Tumor Growth and is a Biomarker for LymphangioleiomyomatosisEndocr Relat CancerMay 9, 2024Erin Gibbons, Manisha Taya, Huixing Wu, Samia H Lopa, Joel Moss, Elizabeth P Henske, Francis X McCormack, Stephen R Hammesserum samples or concentrated cell media samples were used. GPNMB was measured using a GPNMB ELISA kit (DY2550, R&D Systems) and DuoSet ELISA Ancillary Reagent Kit 2 (DY008B, R&D Systems). Absorbance was read at

(13) Glycoprotein non-metastatic melanoma protein B expression correlates with the prognosis of acute liver injury/failureFrontiers in Cell and Developmental BiologyOctober 24, 2023Kotaro Kumagai, Shuji Kanmura, Seiichi Mawatari, Yuko Nakamura, Hiromi Eguchi, Oki Taniyama, Ai Toyodome, Sho Ijuin, Haruka Sakae, Kazuaki Tabu, et al.(HGF) levels Serum GPNMB and HGF levels were measured using the Human Osteoactivin/GPNMB DuoSet ELISA (DY2550, R&D Systems, Minneapolis, MN, United States) and Enzyme Immunoassay (BML, INC., Tokyo, Japan) according

(14) Proteomic analysis of alcohol-associated hepatitis reveals glycoprotein NMB (GPNMB) as a novel hepatic and serum biomarkerAlcohol (Fayetteville, N.Y.)March 1, 2022Harris PS, Michel CR, Yun Y, McGinnis CD, Assiri MA, Ahmadi AR, Sun Z, Roede JR, Burchill MA, Orlicky DJ, et al.concentration of GPNMB in the serum was quantified using a commercial sandwich ELISA kit from R&D Systems (#DY2550) according to the manufacturer’s instructions. The AH patients GPNMB levels are reported as a percentage

(15) Incremental biomarker and clinical outcomes after switch from enzyme therapy to eliglustat substrate reduction therapy in Gaucher diseaseMolecular genetics and metabolism reportsDecember 1, 2021Kleytman N, Ruan J, Ruan A, Zhang B, Murugesan V, Lin H, Guo L, Klinger K, Mistry PK.B Serum concentrations of gpNMB were determined using the enzyme-linked immunosorbent assay (ELISA) kit (DY2550) from R&D systems (Minneapolis, MN) according to the manufacturer's instructions and as described previously

(16) Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and HumansG3 Genes|Genomes|GeneticsNovember 1, 2018Liang-Yu Lin, Sunny Chun Chang, Jim Oâ€™Hearn, Simon T. Hui, Marcus Seldin, Pritha Gupta, Galyna Bondar, Mario Deng, Raimo Jauhiainen, Johanna Kuusisto, et al.enzyme-linked immunosorbent assay kits (R&D systems, Minneapolis, MN) (Catalogue numbers: DY2330 and DY2550, respectively). Statistical analysis The t-test statistic was used to examine differences between

(17) Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microgliaActa neuropathologica communicationsOctober 19, 2018Hüttenrauch M, Ogorek I, Klafki H, Otto M, Stadelmann C, Weggen S, Wiltfang J, Wirths O.CSF and serum samples using commercially available mouse (DY2330) or human Osteoactivin/GPNMB ELISA (DY2550) sets according to the manufacturer’s instructions (R&D systems, Abingdon, UK). Proteins were extracted

(18) Increased GPNMB, phospho-ERK1/2, and MMP-9 in cystic fibrosis in association with reduced arylsulfatase BMolecular genetics and metabolismJune 1, 2018Bhattacharyya S, Feferman L, Sharma G, Tobacman JK.

(19) Validating glycoprotein non-metastatic melanoma B (gpNMB, osteoactivin), a new biomarker of Gaucher diseaseBlood cells, molecules & diseasesFebruary 1, 2018Murugesan V, Liu J, Yang R, Lin H, Lischuk A, Pastores G, Zhang X, Chuang WL, Mistry PK.buffered saline and GPNMB levels were measured using the enzyme-linked immunosorbent assay (ELISA) kits (#DY2550 for human and DY2330 for mouse) from R&D System (Minneapolis, MN) per the manufacturer’s instructions.

(20) Exploratory study on the effect of osteoactivin on muscle regeneration in a rat volumetric muscle loss modelPloS oneJanuary 1, 2017Ma J, Baker AR, Calabro A, Derwin KA.

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Osteoactivin/GPNMB ELISA

Human Osteoactivin/GPNMB DuoSet ELISA

Human Osteoactivin/GPNMB DuoSet ELISA from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Human Osteoactivin/GPNMB DuoSet ELISA from R&D Systems, a Bio-Techne Brand

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