Fig 1: Assessment of the Concentration of Modulating Factors Affecting Oxidative Capacity Following Metformin Stimulation before and after metformin treatment (10–10 µM dose; 30–30 µM dose; 50–50 µM dose; K, reference baseline time point), compared to the reference cell line. NF-κB, nuclear factor kappa B; AMPK, AMP-activated protein kinase; PRKAA1, catalytic subunit alpha-1 of AMP-activated protein kinase; (A) PCS–PCS-201-012; (B) 84 – CCL-84; (C) 54 – CCL-54. Significant differences compared to the reference cell line are indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001.; ****p < 0.000. Statistical analysis was performed using [GraphPad Software, Inc., San Diego, CA, USA.