Fig 1: Expression analysis of CGB5 and CGB7 in Breast Invasive carcinoma using UALCAN: (A and C) Expression of CGB5 & CGB7 in the major subclass of breast cancer with TNBC subtypes (B and D) Expression of CGB5 & CGB7 in major histological subtypes of BRCA. Expression analysis using GEPIA2: (E) Heat map showing the expression of, CGB1, CGB2, CGB, CGB5, CGB7 and CGB8 isoforms in TCGA Normal and tumor (F and G) Expression of CGB5 and CGB7 in different stages of breast cancer.
Fig 2: Co-expressed genes of CGB5 in Breast Invasive Carcinoma (BRCA) using LinkedOmics: (A) Co-expressed genes with CGB5, Pearson test was used for correlation analysis (red dots indicate positive correlation and green dots indicate negative correlation (B) Bar Plot showing the significantly enriched genes of GO (biological process) of CGB5 in BRCA (C) Heat map showing the 50 positively regulated genes with CGB5 and STRING analysis showing the interaction of BRCA1 with positively regulated genes (D) Heat map showing the 50 negatively regulated genes with CGB5 and STRING analysis showing the interaction of BRCA1 with negatively regulated genes. Association between tumor infiltrating immune cells and CGB7 in Breast Invasive Carcinoma (BRCA) in TIMER2: (E) Cancer associated fibroblast (CAF) and Myeloid derived suppressor cells (MDSC) showed positive correlation and Macrophage M2, T-cell CD4+, T cell CD8+, T cell regulatory (Tregs) showed negative correlation. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig 3: Gene outcome of β-hCG isoforms in Breast Invasive Carcinoma (TIMER2): (A) Cumulative survival of CGB in breast invasive carcinoma, BRCA n = 1100, log-ranktest p = 2.46e-02 * (B) Cumulative survival of CGB5 in breast invasive carcinoma n = 1100, log-ranktest p = 1.31e-02 * (C) Cumulative survival of CGB5 in BRCA-basal n = 191, log-ranktest p = 1.87e-03 ** (D) Cumulative survival of CGB8 in BRCA n = 1100, log-ranktest p = 2.39e-02 * Expression of β-hCG in correlation to BRCA1 mutation analysed by TIMER2: (E) Heat map showing the differential expression of CGB isoforms across various tumor types with red box indicating higher expression in mutants (higher level in mutants (p < 0.05,log2FC > 0) (F, G and H) Differential CGB expression level in BRCA (n = 1017), BRCA-Her2 (n = 79) & Lymphoid neoplasm diffuse large B-cell lymphoma DLBC (n = 37) (I) Differential CGB2 expression level in BRCA-Basal (n = 176) (J and K) Differential CGB5 expression level in BRCA-LumA (n = 516) & BRCA (n = 1017) (L) Differential CGB7 expression level in LGG (n = 511). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
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