Fig 1: Genetic inhibition of SDHA prevents age‐induced mitochondrial structural changes and Th17 cytokine production in T cells from older adults. Quantification of SDHA protein expression after siRNA‐mediated knockdown of SDHA (a) Quantification of localization of SDHA with mitochondrial protein TOM20 (b) representative images (c). Representative images of mitochondrial network analysis performed on T cells ± SDHA siRNA (d) quantification of branches (e) mitochondrial number (f). 3D IMARIS analysis of mitochondrial volume (g) IL17A/F heterodimer levels after SDHA siRNA, assessed via ELISA assay (h). N = 3–5 (a–h) adults in each group. Mann–Whitney test. *p < 0.05 vs. Con siRNA.