Fig 1: The effect of TNF and ATA exposure on HUVEC and fibroblast expression levels of THBD, PROCR, and TFPI, and HUVEC expression of F3, F9, and F10. The changes in gene expression of the surface coagulation regulatory proteins were measured in untreated HUVECs and fibroblasts (black), cells exposed to 10 ng/ml TNF (red), and cells exposed to 30 µg/ml ATA (blue) for 24 hours. Graphs show fold-changes in expression of (a) THBD, PROCR, and TFPI and (b) F3, F9, and F10 in HUVECs and (c) THBD, PROCR, and TFPI in fibroblasts (means + SD). Number of gene measurements per experimental condition, HUVECs: THBD, n = 6; PROCR, n = 4–5; TFPI, n = 3; F3, n = 3–4; F9, n = 4; F10, n = 3; for fibroblasts, each gene was measured 4 times under each experimental condition. *p < 0.05.