Fig 1: In Ldlr−/− cecal xenograft mice simvastatin regulates PD-L1 expression in CRC by reducing cholesterol levels. (A) In vivo bioluminescence imaging after simvastatin treatment reveals tumor progression. (B) Quantification of bioluminescence intensity for each mouse, with the average value calculated for each cohort. Data are presented as mean ± SEM (n = 5). (C) Simvastatin-treated colon tissue HE, Ki67 staining, PD-L1 and CD3 staining. Serum levels of (D) Cholesterol and LDL/VLDL, (E) IL2, (F) TNF-α, and (G) TNF-γ were measured
Supplier Page from Abcam for Mouse TNF alpha ELISA Kit