Fig 1: Trauma shows unique features in clotting factors in humans. The activity and protein concentration of each clotting factor, FV (A), FVII (B), FVIII (C), FIX (D), FX (E), FXI (F) and FXII (G) was measured using human plasma from trauma patients (n = 22) and healthy controls (n = 10) as described in Methods. Ratio of each clotting factor was calculated by dividing the activity of each factor with protein concentration. Data represent mean ± SEM. ns = not significant. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001 vs. control. FV ratio, FVII concentration, FVIII activity, FIX concentration, FXI ratio and FXII ratio panels (Mann-Whitney U test), others (Student's t-test).