Fig 1: Increased MICA/B expression on tumor cells after 7C6 mAb pretreatment. A): MICA/B expression on HuCCT-1 cells after treatment with 7C6 mAb and isotype control. B): frequency of CD107a+ NK cells from HC in the presence of 7C6 mAb using 7C6- and isotype-pretreated HuCCT-1 cells as target. The parametric paired t tests were used to compare data. C): representative dot plots showing the frequency of CD3-CD56+ CD107a+ NK cells shown in panel b. D): MICA/B expression (MFI) on patient-derived tumor cell lines (n = 10) after treatment with 7C6 mAb and isotype control. The non-parametric Wilcoxon t test was used to compare data. E): representative histograms showing MICA/B expression on patient-derived tumor cell lines illustrated in panel D.
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