Fig 1: Platelet depletion reduces DND after SAH.a–c, After SAH, mice depleted of platelets (PF4-DTR + DT), compared with nondepleted (WT + DT) mice, had better neuroscore (a mean with s.e.m.), less DND (b), and fewer brain microthrombi (c) (scale bar = 100 μm, representative images of MSB-stained brain slices with yellow asterisks marking selected microthrombi (best observed zoomed in)). All mice received the entire DT regimen. For neuroscore (a), sham n = 8 per sex, female WT SAH n = 20–30, female (PF4-DTR) SAH n = 27–29, male WT SAH n = 25–30, and male (PF4-DTR) SAH n = 30–31. For DND (b), WT SAH n = 30 per sex, and (PF4-DTR) SAH n = 29 female and n = 31 male. *P < 0.05 WT sham versus WT SAH, #P < 0.05 (PF4-DTR) sham versus (PF4-DTR) SAH, and †P < 0.05 WT SAH versus (PF4-DTR) SAH.