Human Progranulin DuoSet ELISA DY2420 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemHuman Progranulin DuoSet ELISA
CompanyR&D Systems, a Bio-Techne Brand
Price $890.00Supplier Page View Company Product Page
Catalog NumberDY2420
Quantity1 Kit (for 15 Plates)
ApplicationsELISA
Detection Range62.50 - 4000 pg/mL
ReactivityHuman
Detection TargetProgranulin/PGRN
StorageStore the unopened product at 2 - 8 °C. Do not use past expiration date
NCBI Full Gene Namegranulin precursor
NCBI Gene AliasesCLN11, GEP, GP88, PCDGF, PEPI, PGRN

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient MiceResearchSquareFebruary 3, 2026Hayk Davtyan, Sarah Naguib, Yuliya Voskobiynyk, Jean Paul Chadarevian, Joia K. Capocchi, Jeannie L. Giacchino, Ghazaleh Eskandari-Sedighi, Vivianna DeNittis, Jeremy B. Ford, Ani Agababian, et al.using commercially available ELISAs following the manufacturer guidelines to measure human Progranulin (DY2420; R&D Systems), mouse Myelin Basic Protein (MBP; ABIN6957934; antibodies-online.com), and V-PLEX Plus

(2) Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient MicebioRxivJanuary 17, 2026Hayk Davtyan, Sarah Naguib, Yuliya Voskobiynyk, Jean Paul Chadarevian, Joia K. Capocchi, Jeannie L. Giacchino, Ghazaleh Eskandari-Sedighi, Vivianna DeNittis, Jeremy B. Ford, Ani Agababian, et al.using commercially available ELISAs following the manufacturer guidelines to measure human Progranulin (DY2420; R&D Systems), mouse Myelin Basic Protein (MBP; ABIN6957934; antibodies-online.com), and V-PLEX Plus

(3) Development of AL101 (GSK4527226), a progranulin-elevating monoclonal antibody, as a potential treatment for Alzheimer's diseaseAlzheimers Res TherJuly 25, 2025Balasubrahmanyam Budda, Ananya Mitra, Lovingly Park, Hua Long, Michael Kurnellas, Nga Bien-Ly, William Estacio, Brady Burgess, Grace Chao, Tina Schwabe, et al.instructions (AdipoGen Life Sciences; Cat. #AG-45A-0043YEK-KI01; Lot #K5211908 or R&D Systems; Cat. #DY2420; Lot #P325650). Optical densities were measured at 450 nm using a Molecular Devices M5 or a Biotek Synergy H1

(4) Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiencyCell reportsDecember 24, 2024Root J, Mendsaikhan A, Taylor G, Merino P, Nandy S, Wang M, Araujo LT, Ryu D, Holler C, Thompson BM, et al.,Vector Laboratories,Cat#PK-6100 Mouse GPNMB ELISA,R and D Systems,Cat#DY2330 Human PGRN ELISA,R and D Systems,Cat#DY2420 Deposited data,Deposited data,Deposited data Mouse brain proteomic dataset,This paper; https://www.ebi.ac.uk/pride,PXD041095 Mouse

(5) An anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradationFrontiers in ImmunologyAugust 8, 2024Moira Ek, Johan Nilvebrant, Per-Åke Nygren, Stefan Ståhl, Hanna Lindberg, John Löfblomcollected, and PGRN concentrations were quantified using Human Progranulin DuoSet ELISA (R&D Systems DY2420), according to the manufacturer’s instructions. Absorbance was measured at 450 and 540 nm using a ClarioStar

(6) Progranulin protects against Clostridioides difficile infection by enhancing IL-22 productionGut microbesJanuary 1, 2024Huang J, Liu B, Liu Y, You W, Zhao P, Liu Y, Wang K, Lai X, Xu B, Cao J.Human serum PGRN and IL-22 were measured using the Human Progranulin DuoSet ELISA Kit (R&D system, DY2420) and ELISA MAX™ Deluxe Set Human IL-22 (Biolegend 434,504) according to the manufacturer’s instructions. Quantitative real-time PCR

(7) Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodentsNature communicationsSeptember 19, 2023He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg LU, Nilsson A, Mamula D, Kehr J, Zareba-Paslawska J, Biverstål H, et al.

(8) AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b(-/-)Grn(-/-) miceiScienceJuly 21, 2023Feng T, Minevich G, Liu P, Qin HX, Wozniak G, Pham J, Pham K, Korgaonkar A, Kurnellas M, Defranoux NA, et al.commercial assays,Critical commercial assays ,, Human Progranulin DuoSet ELISA Kit,R&D Systems,Cat# DY2420 Cone-bottom collection tube,Sarstedt,Cat# 41.1500.005 TrueBlack Lipofuscin Autofluorescence Quencher,Biotium,Cat#

(9) Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-RegulationFrontiers in neuroscienceJanuary 1, 2020Miyakawa S, Sakuma H, Warude D, Asanuma S, Arimura N, Yoshihara T, Tavares D, Hata A, Ida K, Hori Y, et al.

(10) Aberrant progranulin, YKL-40, cathepsin D and cathepsin S in Gaucher diseaseMolecular Genetics and MetabolismSeptember 1, 2019Yuliya Afinogenova, Jiapeng Ruan, Ruhua Yang, Nathaniel Kleytman, Gregory Pastores, Andrew Lischuk, Pramod K. Mistryof progranulin were determined in duplicate using the enzyme-linked immunosorbent assay (ELISA) kit (DY2420) from R&D systems (Minneapolis, MN) according to the manufacturer’s instructions. 2.3 YKL-40 Levels

(11) Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic LeukemiaCancersJune 13, 2019Schulze-Edinghausen L, Dürr C, Öztürk S, Zucknick M, Benner A, Kalter V, Ohl S, Close V, Wuchter P, Stilgenbauer S, et al.

(12) Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individualsJournal of neuroinflammationApril 15, 2015Suh HS, Lo Y, Choi N, Letendre S, Lee SC.concentrations were within the linear range of detection for the assay. Progranulin was measured by ELISA (DY2420, R&D Systems), as reported [43]. All samples were tested in duplicate and concentrations interpolated

(13) Evidence of the innate antiviral and neuroprotective properties of progranulinPloS oneJanuary 1, 2014Suh HS, Lo Y, Choi N, Letendre S, Lee SC.CXCL10/IP-10 (EMD Millipore, Billerica, MA). PGRN ELISA was performed using human antibody DuoSet (DY2420, R&D Systems, Minneapolis, MN). All samples were diluted until the final concentrations were within

(14) Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12)PloS oneJanuary 1, 2012Suh HS, Choi N, Tarassishin L, Lee SC.

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Progranulin/PGRN ELISA

Human Progranulin DuoSet ELISA

Human Progranulin DuoSet ELISA from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Human Progranulin DuoSet ELISA from R&D Systems, a Bio-Techne Brand

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