The Rabbit anti-human Histone deacetylase 4 polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to HDAC4, and Histone Deacetylase 4. This antibody recognizes Human antigen. The Rabbit anti-human Histone deacetylase 4 polyclonal Antibody has been shown to work in the following applications: ELISA, and Immunohistochemistry.
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. This protein belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3