PAX6 (Stem Cell Marker) MBS438897 from MyBioSource.com

Product Specs
ItemPAX6 (Stem Cell Marker)
CompanyMyBioSource.com
Price $275.00Supplier Page View Company Product Page
Catalog NumberMBS438897
Quantity0.1 mg
ApplicationsFlow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
ConcentrationPurified Ab with BSA and Azide at 200ug/ml
Conjugate/TagUnconjugated
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ReactivityHuman
TargetPAX6
IsotypeIgG1 kappa
Molecular WeightAntigen: 47kDa
CloneSPM612
HostMouse
ImmunogenPax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain
NCBI Full Gene Namepaired box 6
NCBI Gene AliasesMGDA, AN, AN2, WAGR, FVH1, D11S812E
ClonalityMonoclonal